Coronary Arterial & Microvascular

Fluid-structure Interactions:

Evolving Concepts & Investigative Approaches

National Heart and Lung Institute

Guy Scadding Building , Dovehouse Street

London, SW3 6LY

17 September 2012

Symposium Coordinator

Dr. Philip Kilner, Royal Brompton Hospital and Imperial College, UK


This one day symposium is intended for cardiologists and trainees interested in the investigation and management of coronary vascular disease, and for scientist in related biomedical fields.

CPD : The meeting has been approved for 6 credits by the Royal College of Physicians.

The aims will be:

To consider the current investigative and management approaches to coronary artery disease.

To illustrate the dynamic interactions between coronary blood flow, arterial boundaries, myocardial tissue dynamics and spatio-temporal pressure variations.

To consider how these can be altered in coronary artery and myocardial disease.

To apply understanding of these principles to the pathophysiology of coronary disease with a view to achieving more appropriate interventions based on novel investigative approaches.

To consider the evolving investigative approaches of non-invasive cardiovascular magnetic resonance, invasive coronary optical coherence tomography and high fidelity pressure wire measurements of the adenosine-indepedent instantaneous wave-free ratio (iFR)

The meeting includes presentations and discussions on two important recent studies on:

Adenosine-independent evaluation of coronary stenoses:                   

The assessment of myocardial perfusion by CMR:                          

Each could be considered potentially game-changing, but controversial. The symposium offers opportunities to hear from and question the leading authors of these studies.


Dr Justin E Davies, National Heart and Lung Institute, Imperial College, London, UK

Dr Javier Escaned, Cardiovascular Institute, Hospital Clínico San Carlos, Madrid, Spain

Dr Ricardo Petraco, National Heart and Lung Institute, Imperial College, London, UK

Professor Yun Xu, Department of Chemical Engineering, Imperial College, London, UK

Professor Kim Parker, Department of Bioengineering, Imperial College,London, UK

Dr Philip Kilner, Royal Brompton Hospital and Imperial College, London,UK

Dr Christian Poelma, Delft University of Technology, the Netherlands

Dr Eliana Reyes, Royal Brompton Hospital and Imperial College, London,UK

Dr Sven Plein, Multidisciplinary Cardiovascular Research Centre, University of Leeds, UK

Dr Sayan Sen, National Heart and Lung Institute, Imperial College, London, UK

Dr Ranil De Silva, National Heart and Lung Institute, Imperial College, London, UK


Monday 17th September 2012

8:30         Registration and Coffee

9.00         Introductory remarks                                          Dr. P. Kilner                                                                                

9.15        Coronary artery disease investigation and management: overview                                                                                                                 Dr R De Silva

9.45       Angiography versus functional flow reserve:Intro. Dr. J Davies & Dr. S Sen 

9.55                                                            Experimental work                Dr R De Silva

10.15                                                         Fluid dynamic analysis             Prof. Y. Xu

10.30      Questions and panel discussion : Chair: Dr P. Kilner                                        

10.45             Refreshments

11.15       Arterial wave intensity analysis and coronary flow           Prof. K. Parker                                             

11.40       The dynamic structure of the myocardium                               Dr. P. Kilner

12.00        Adenosine-independent evaluation of coronary stenoses:  Dr. J.Davies                 

12.40        Questions and panel discussion                              Chair: Dr. J. Escaned

1.00                Lunch

2.00         Myocardial perfusion and diffusion dynamics                        Dr. C. Poelma

2.20         Methods for evaluating myocardial viability and perfusion       Dr. E. Reyes

2.50        Viability and perfusion by Cardiovascular Magnetic Resonance Dr S. Plein

3.30                Refreshments

4.00       Towards a comprehensive assessment of the coronary circulation                                                                                                               Dr. J. Escaned 

4.30       Questions and panel discussion                                    Chair: Dr. R.De Silva

5.00                Close


For registration of interest please contact Ercoftac / Ms. Magdalena Jakubczak (Admin Manager):

Please note: The lecture theatre accommodates 110: registration is subject to availability

Guidance on fees:

Consultants and Senior Scientists: £165 pp

Students and Trainees: £50.

The fee includes refreshments, lunch and lecture pdfs.

Please note accommodation is not part of the fee.

Crown House
72 Hammersmith Road
London, W14 8TH  or

Tel: +44 (0)207 559 1430                   +44(0)207 559 1429              Fax: +44 (0)207 559 1428

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